![]() This suggests other factors may have an effect on CEA/CH expression, i.e. The phenomenon is common enough that many ophthalmologists recommend clinical examination to be focused on puppies/young dogs. The term ?go normal? has been applied to cases where post-natal development obscures the choroidal hypoplasia which is the key diagnostic feature, so that adult dogs have ?normal? appearance despite being genotypically affected. This has led to some adult dogs in this category being termed so-called ?go normals?. Collie eye anomaly (CEA) is a complex hereditary ocular disorder which is characterized by regional hypoplasia of choroids, the highly vascularized layer of. In some cases, the phenotype can vary to include colobomas and staphylomas in the optic nerve head and adjacent tissues ? which may be the only visible abnormality. This layer of tissue is responsible for supplying nutrients and blood to the retina. It can also be referred to as choroidal hypoplasia (CH) due to the fact that the choroid layer of tissue is thinner in dogs suffering from the disease. Inheritance of CEA/CH is approximately autosomal recessive. Collie eye anomaly (CEA) is an inherited disease that affects several dog breeds. The severe forms can result in serious vision loss or blindness in some cases. ![]() However, dogs with mild disease can produce severely affected offspring. Most often the disease presents as a mild form in affected dogs and the presence of the disease can only be detected upon ophthalmologic examination the dog retains normal vision throughout life. Retinal Atrophy, and any other eye abnormalitypresent. The clinical effects vary greatly among affected dogs within one breed, between parent and offspring and even within a litter. The eyes of 160 Collies were examined for Collie Eye Anomaly, Progressive. Since the choroid layer does not develop normally from the start, the primary abnormality can be diagnosed at a very young age by an opthamologist. ![]() CEA/CH causes abnormal development of the choroid - an important layer of tissue under the retina of the eye.
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